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Exploration of the Scope of Pt‐Catalyzed C–F Activation
Author(s) -
Keyes Lauren,
Sun Alex D.,
Love Jennifer A.
Publication year - 2011
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201100478
Subject(s) - scope (computer science) , chemistry , catalysis , combinatorial chemistry , aryl , methylation , organic chemistry , biochemistry , computer science , alkyl , gene , programming language
We recently reported methods for the catalytic methylation and methoxylation of polyfluoroaryl imines utilizing [Pt 2 Me 4 (SMe 2 ) 2 ] as a precatalyst. These methodologies provide a novel route to partially functionalized aryl fluorides, which have potential utility as building blocks for the synthesis of pharmaceuticals and materials. We report herein efforts to expand the scope of these processes, particularly the choice of directing group. Comparisons to the previously reported scope of Pt II ‐catalyzed methylation and methoxylation are described.