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Efficacy of C–N Coupling Reactions with a New Multinuclear Copper Complex Catalyst and Its Dissociation into Mononuclear Species
Author(s) -
Zou Yan,
Lin Haisheng,
Maggard Paul A.,
Deiters Alexander
Publication year - 2011
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201100399
Subject(s) - chemistry , pyridazine , catalysis , dissociation (chemistry) , copper , homogeneous catalysis , coupling reaction , combinatorial chemistry , inorganic chemistry , medicinal chemistry , organic chemistry
A new tetranuclear copper(I)–pyridazine (pda)/rhenate hybrid has been synthesized under hydrothermal conditions and structurally characterized by X‐ray crystallography. The activity of this catalyst, as well as its dissociation into mononuclear species, was investigated in homogeneous C–N arylation reactions. A variety of N ‐arylamides and ‐azoles were synthesized in good to excellent yields, revealing the effect of polynuclear versus mononuclear Cu complexation in this type of coupling reaction.