Premium
Chiral Heterodisulfoxide Ligands in Rhodium‐Catalyzed Asymmetric 1,4‐Addition of Arylboronic Acids to Chromenones
Author(s) -
Han Fuzhong,
Chen Guihua,
Zhang Xiangyang,
Liao Jian
Publication year - 2011
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201100387
Subject(s) - chemistry , rhodium , yield (engineering) , catalysis , benzene , enantioselective synthesis , combinatorial chemistry , organic chemistry , medicinal chemistry , stereochemistry , materials science , metallurgy
A new family of benzene‐based chiral heterodisulfoxide ligands L1 – L5 was synthesized in a single step. These disulfoxide ligands were applied in the rhodium‐catalyzed asymmetric 1,4‐addition of arylboronic acids to chromenones. The addition of diverse arylboronic acids to chromenones proceeds smoothly in up to 70 % yield with up to 95 % ee .