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Enzymatic Total Synthesis of Banana Volatile ( S )‐2‐Pentyl ( R )‐3‐Hydroxyhexanoate
Author(s) -
Kallergi Maria,
Kalaitzakis Dimitris,
Smonou Ioulia
Publication year - 2011
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201100368
Subject(s) - chemistry , transesterification , yield (engineering) , enzyme , organic chemistry , nuclear chemistry , catalysis , materials science , metallurgy
The banana volatile ( S )‐2‐pentyl ( R )‐3‐hydroxyhexanoate has been synthesized in 79 % yield and high optical purity (>99 % ee , >99 % de ) starting from methyl 3‐oxohexanoate and 2‐pentanone. The synthetic method consists of three steps and the key reactions are enzymatic reduction and enzymatic transesterification.