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Total Synthesis of (–)‐Corynantheidine by Nickel‐Catalyzed Carboxylative Cyclization of Enynes
Author(s) -
Mizuno Takashi,
Oonishi Yoshihiro,
Takimoto Masanori,
Sato Yoshihiro
Publication year - 2011
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201100147
Subject(s) - chemistry , catalysis , nickel , total synthesis , combinatorial chemistry , medicinal chemistry , organic chemistry
The total synthesis of (–)‐corynantheidine has been achieved through Ni 0 ‐mediated carboxylative cyclization as the key reaction step with incorporation of CO 2 , and this cyclization was also successfully expanded to the catalytic reaction by using Et 2 Zn in the presence of an excess amount of DBU.
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