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One‐Pot Synthesis of Novel Antiproliferative 9‐Aminoacridines
Author(s) -
Gellerman Gary,
Waintraub Sagiv,
Albeck Am,
Gaisin Vladimir
Publication year - 2011
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201100133
Subject(s) - chemistry , combinatorial chemistry , quinone , acridine derivatives , scope (computer science) , stereochemistry , programming language , computer science
Highly efficient one‐pot syntheses of antiproliferative 9‐aminoacridine (9‐AA) derivatives are described. Simple S N Ar and addition/elimination reactions, using readily accessible starting materials, give a fast entry to novel 9‐(pyridylamino)acridines, 9‐(pyrimidinylamino)acridines and potential “dual‐function” bioreductive 9‐(acridinylamino)quinone intercalators. The synthetic routes reported in this work are general and readily applicable, significantly expanding the range and scope of potential 9‐AA anticancer candidates.