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Use of Acylhydrazine‐ and Acylhydrazone‐Type Ligands to Promote CuI‐Catalyzed C–N Cross‐Coupling Reactions of Aryl Bromides with N‐Heterocycles
Author(s) -
Li Liuyi,
Zhu Lei,
Chen Dagui,
Hu Xuelei,
Wang Ruihu
Publication year - 2011
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201100112
Subject(s) - chemistry , aryl , steric effects , catalysis , coupling reaction , combinatorial chemistry , ullmann reaction , medicinal chemistry , stereochemistry , organic chemistry , alkyl
A series of ten acylhydrazine‐ and acylhydrazone‐type ligands were designed and synthesized. Their electronic and steric properties were easily modified and tuned by varying the substituents in the vicinity of the acylhydrazine and acylhydrazone units. The effect of ligands on the catalytic activity of Ullmann reactions was assessed by using a combination of these ligands with CuI. The catalytic system is very efficient for the C–N coupling reaction of azoles with aryl and heteroaryl bromides.