Asymmetric Transfer Hydrogenation of Aromatic Ketones Using Rhodium Complexes of Chiral N‐Heterocyclic Carbenes Derived from ( S )‐Pyroglutamic Acid | Zendy

Aupoix Audrey | Zendy; Bournaud Chloée | Zendy; VoThanh Giang | Zendy

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Asymmetric Transfer Hydrogenation of Aromatic Ketones Using Rhodium Complexes of Chiral N‐Heterocyclic Carbenes Derived from ( S )‐Pyroglutamic Acid

Author(s) -

Aupoix Audrey,

Bournaud Chloée,

VoThanh Giang

Publication year - 2011

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201100100

Subject(s) - chemistry , pyroglutamic acid , transfer hydrogenation , rhodium , noyori asymmetric hydrogenation , catalysis , organic chemistry , combinatorial chemistry , metal , enantioselective synthesis , amino acid , ruthenium , biochemistry

A new and flexible procedure for the preparation of chiral azolium salts derived from ( S )‐pyroglutamic acid has been developed. The efficiency of these ligands has been evaluated in the metal‐catalyzed asymmetric transfer hydrogenation of aromatic ketones in isopropanol. Good enantioselectivities up to 90 % ee were observed.

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