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Asymmetric Transfer Hydrogenation of Aromatic Ketones Using Rhodium Complexes of Chiral N‐Heterocyclic Carbenes Derived from ( S )‐Pyroglutamic Acid
Author(s) -
Aupoix Audrey,
Bournaud Chloée,
VoThanh Giang
Publication year - 2011
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201100100
Subject(s) - chemistry , pyroglutamic acid , transfer hydrogenation , rhodium , noyori asymmetric hydrogenation , catalysis , organic chemistry , combinatorial chemistry , metal , enantioselective synthesis , amino acid , ruthenium , biochemistry
A new and flexible procedure for the preparation of chiral azolium salts derived from ( S )‐pyroglutamic acid has been developed. The efficiency of these ligands has been evaluated in the metal‐catalyzed asymmetric transfer hydrogenation of aromatic ketones in isopropanol. Good enantioselectivities up to 90 % ee were observed.