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Cinchona Alkaloid Catalyzed Enantioselective Chlorination of 3‐Aryloxindoles
Author(s) -
Zhao MeiXin,
Zhang ZhiWang,
Chen MingXiao,
Tang WenHao,
Shi Min
Publication year - 2011
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201100061
Subject(s) - chemistry , cinchona , enantioselective synthesis , enantiomer , organocatalysis , chlorine , organic chemistry , catalysis , alkaloid , enantiomeric excess , cinchonidine , aryl , cinchonine , cinchona alkaloids , alkyl
O ‐Benzoylquinidine is an effective organocatalyst for the asymmetric chlorination of 3‐aryloxindoles by using easily available N ‐chlorosuccinimide (NCS) as chlorine source to give the corresponding 3‐aryl‐3‐chlorooxindoles in excellent yields and up to 93 % enantiomeric excess.
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