Chiral Thiourea‐Catalyzed Asymmetric Michael Addition of β‐Oxo Phosphonate to Nitro Olefins: Convenient Synthesis of Optically Active β‐Oxo Phosphonates | Zendy

Hu Kuang | Zendy; Liu Tao | Zendy; Lu A. D. | Zendy; Liu Yunfeng | Zendy; Wang Youming | Zendy; Wu Guiping | Zendy; Zhou Zhenghong | Zendy; Tang Chuchi | Zendy

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Chiral Thiourea‐Catalyzed Asymmetric Michael Addition of β‐Oxo Phosphonate to Nitro Olefins: Convenient Synthesis of Optically Active β‐Oxo Phosphonates

Author(s) -

Hu Kuang,

Liu Tao,

Lu A. D.,

Liu Yunfeng,

Wang Youming,

Wu Guiping,

Zhou Zhenghong,

Tang Chuchi

Publication year - 2011

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201100029

Subject(s) - chemistry , thiourea , michael reaction , phosphonate , cinchonine , nitro , bifunctional , enantioselective synthesis , catalysis , organocatalysis , organic chemistry , optically active , cinchona alkaloids , combinatorial chemistry , alkyl

β‐Oxo phosphonates have been proven to be alternative Michael donors in Michael addition reactions to nitro olefins in the presence of cinchonine‐based bifunctional thiourea, affording a direct and atom‐economic approach to the efficient construction of synthetically and biologically valuable chiral acyclic α‐substituted β‐oxo phosphonates with high levels of enantioselectivity (up to 98 % ee ).

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