Premium
Synthesis and DNA Interaction of Platinum Complex/Peptide Chimera as Potential Drug Candidates (Eur. J. Org. Chem. 32/2010)
Author(s) -
Damian Mariana S.,
Hedman Hanna K.,
Elmroth Sofi K. C.,
Diederichsen Ulf
Publication year - 2010
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201090088
Subject(s) - chemistry , cisplatin , dna , nucleobase , peptide , platinum , stereochemistry , covalent bond , combinatorial chemistry , molecule , anticancer drug , drug , biochemistry , organic chemistry , catalysis , pharmacology , medicine , surgery , chemotherapy
The cover picture shows the covalent DNA binding of cisplatin‐like complexes. These molecules were designed as hybrids between the platinum coordination site and positively charged peptides, which involves the covalent binding of one or two nucleobases by cisplatin‐analogous platinum complexes and the bending of double‐stranded DNA initiated by the peptide chain. An optimization of cisplatin‐like anticancer drugs is intended. Binding of cisplatin analogs is facilitated by simultaneous DNA bending. Details are discussed in the article by U. Diederichsen et al. on p. 6161 ff.