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Graphical Abstract: Eur. J. Org. Chem. 29/2010
Publication year - 2010
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201090081
Subject(s) - chemistry , stereochemistry , furan , antifungal , protein data bank (rcsb pdb) , candida albicans , cover (algebra) , organic chemistry , microbiology and biotechnology , mechanical engineering , biology , engineering
The cover picture shows a very direct route to the synthesis of 2‐substituted benzo[ b ]furans in the shadow of the X‐ray structure of N‐myristoyltransferase (E.C. 2.3.1.97) obtained from Candida albicans , which is inhibited by a synthetic benzo[ b ]furan (PDB reference 1IYL, S. Sogabe et al., Chem. Biol. 2002 , 9 , 1119). This synthetic route provides an excellent platform for the exploration of potential antifungal agents of this type. Details are discussed in the article by L. M. Geary and P. G. Hultin on p. 5563 ff.