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2‐Substituted Benzo[ b ]furans from ( E )‐1,2‐Dichlorovinyl Ethers and Organoboron Reagents: Scope and Mechanistic Investigations into the One‐Pot Suzuki Coupling/Direct Arylation (Eur. J. Org. Chem. 29/2010)
Author(s) -
Geary Laina M.,
Hultin Philip G.
Publication year - 2010
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201090079
Subject(s) - chemistry , stereochemistry , antifungal , furan , suzuki reaction , reagent , organic chemistry , catalysis , palladium , medicine , dermatology
The cover picture shows a very direct route to the synthesis of 2‐substituted benzo[ b ]furans in the shadow of the X‐ray structure of N‐myristoyltransferase (E.C. 2.3.1.97) obtained from Candida albicans , which is inhibited by a synthetic benzo[ b ]furan (PDB reference 1IYL, S. Sogabe et al., Chem. Biol. 2002 , 9 , 1119). This synthetic route provides an excellent platform for the exploration of potential antifungal agents of this type. Details are discussed in the article by L. M. Geary and P. G. Hultin on p. 5563 ff.