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Graphical Abstract: Eur. J. Org. Chem. 26/2010
Publication year - 2010
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201090072
Subject(s) - chemistry , glycoconjugate , phosphoramidate , peptide , glycopeptide , combinatorial chemistry , glycosyl , carbohydrate , conjugate , cover (algebra) , stereochemistry , organic chemistry , biochemistry , mechanical engineering , engineering , mathematical analysis , mathematics , antibiotics
The cover picture shows the synthesis of a novel class of carbohydrate–peptide conjugates, which proceeds by a Staudinger‐phosphite reaction of glycosyl azides with phosphitylated peptides. The synthetic protocol is easy to perform, as the carbohydrate has to be added to the solid‐supported peptide before the resulting glycoconjugate is cleaved from the resin by TFA treatment. The obtained phosphoramidate‐linked glycopeptides derived from the dimethyl phosphitylated peptides are stable under acidic and physiological conditions. Details are discussed in the article by C. P. R. Hackenberger et al. on p. 5004 ff. The authors thank Nico Zapke and the “cowema.com medienlabor” for their contribution in designing the cover picture.