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Pyrrolysine Analogs for Translational Incorporation into Proteins (Eur. J. Org. Chem. 22/2010)
Author(s) -
Fekner Tomasz,
Li Xin,
Chan Michael K.
Publication year - 2010
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201090058
Subject(s) - methanosarcina barkeri , chemistry , amino acid , transfer rna , stop codon , biochemistry , stereochemistry , gene , rna , methanogenesis , organic chemistry , methane
The cover picture shows the X‐ray crystal structure of the monomethylamine methyltransferase from Methanosarcina barkeri . It was central to the discovery of pyrrolysine, the 22nd genetically encoded amino acid. The picture is also decorated with the structures of pyrrolysine and some of its analogs. They can be incorporated into proteins in response to an otherwise non‐sense amber (UAG) codon upon action of pyrrolysyl‐tRNA Pyl synthetases from various Methanosarcinaceae working in tandem with their cognate tRNAs. Details are presented in the Microreview by M. K. Chan et al. on p. 4171 ff. The scarlet‐and‐gray background represents the colors of The Ohio State University.