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Graphical Abstract: Eur. J. Org. Chem. 17/2010
Publication year - 2010
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201090045
Subject(s) - chemistry , deoxyribozyme , oligonucleotide , nucleoside , homogeneous , stereochemistry , hydrogen bond , amide , combinatorial chemistry , dna , organic chemistry , molecule , biochemistry , physics , thermodynamics
Abstract The cover picture shows the formation of a 15‐base‐long DNA strand from individual nucleosides. The light‐blue nucleoside has been modified so that it can form an amide bond with a phosphanylcarboxylic acid, once the strand has been prepared. In this way, artificial “metallo‐DNAzymes” can be developed by complex formation of transition metals with phosphane‐modified oligonucleotides, bridging the cap between homogeneous and biocatalysis. This is symbolised in the background by the famous Swilcan Bridge at the 18th hole of the Old Course of St Andrews, Scotland. Details are discussed in the article by P. C. J. Kamer et al. on p. 3229 ff.