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The 3‐Hydroxypiperidine Skeleton: Key Element in Natural Product Synthesis (Eur. J. Org. Chem. 15/2010)
Author(s) -
Wijdeven Marloes A.,
Willemsen Jorgen,
Rutjes Floris P. J. T.
Publication year - 2010
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201090037
Subject(s) - chemistry , natural product , stereochemistry , enantioselective synthesis , cover (algebra) , combinatorial chemistry , organic chemistry , catalysis , mechanical engineering , engineering
The cover picture shows an artistic impression of the interaction of different types of 3‐hydroxypiperidine‐containing natural products with an imaginary receptor protein. The 3‐hydroxypiperidine motif represents a privileged structural element that occurs in a large variety of biologically relevant compounds displaying a range of activities. Examples include the natural products 3‐hydroxypipecolic acid, prosopinine, morusimic acid D, cassine and febrifugine. Enantioselective synthetic strategies to these compounds are presented in the Microreview by F. P. J. T. Rutjes et al. on p. 2831 ff. Cover picture design by Dr. Sander S. van Berkel.