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Synthesis and Optical Properties of Cyanine Dyes as Fluorescent DNA Base Substitutions for Live Cell Imaging (Eur. J. Org. Chem. 7/2010)
Author(s) -
Holzhauser Carolin,
Berndl Sina,
Menacher Florian,
Breunig Miriam,
Göpferich Achim,
Wagenknecht HansAchim
Publication year - 2010
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201090013
Subject(s) - cyanine , chemistry , dna , fluorescence , nucleic acid , base pair , combinatorial chemistry , base (topology) , thiazole , stereochemistry , biophysics , biochemistry , optics , physics , biology , mathematical analysis , mathematics
The cover picture shows how thiazole orange and its elongated derivative TO3 can be combined as a fluorescent base pair for imaging nucleic acids inside living cells. Both dyes were incorporated synthetically as DNA base substitutions and are able to display DNA dehybridization by changing color from red to green. Details are discussed in the article by H.‐A. Wagenknecht et al. on p. 1239 ff.