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Copper‐Catalyzed Direct Synthesis of 3‐Arylindoles
Author(s) -
Murru Siva,
Gallo August A.,
Srivastava Radhey S.
Publication year - 2011
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201001745
Subject(s) - deoxygenation , annulation , chemistry , catalysis , alkyne , copper , combinatorial chemistry , organic chemistry
A direct method for the preparation of various 3‐arylindoles from their corresponding nitrosoarenes has been developed. Various substituted nitrosoarenes and alkynes were employed to obtain substituted indoles by using a Cu II –Cu 0 catalytic system. This is a two‐step method that involves annulation of the nitrosoarene and alkyne followed by deoxygenation to give 3‐arylindoles.