Premium
Copper‐Catalyzed Direct Synthesis of 3‐Arylindoles
Author(s) -
Murru Siva,
Gallo August A.,
Srivastava Radhey S.
Publication year - 2011
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201001745
Subject(s) - deoxygenation , annulation , chemistry , catalysis , alkyne , copper , combinatorial chemistry , organic chemistry
A direct method for the preparation of various 3‐arylindoles from their corresponding nitrosoarenes has been developed. Various substituted nitrosoarenes and alkynes were employed to obtain substituted indoles by using a Cu II –Cu 0 catalytic system. This is a two‐step method that involves annulation of the nitrosoarene and alkyne followed by deoxygenation to give 3‐arylindoles.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom