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A Facile One‐Pot Access to Dibenzo[ b , e ]oxepines by a Lewis Acid Catalysed Tandem Reaction
Author(s) -
Reddy Chada R.,
Ramesh Palacherla,
Rao Nagavaram N.,
Ali Saiyed A.
Publication year - 2011
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201001739
Subject(s) - chemistry , tandem , catalysis , lewis acids and bases , nucleophile , lewis acid catalysis , medicinal chemistry , cascade reaction , organic chemistry , carbon fibers , reaction conditions , combinatorial chemistry , materials science , composite number , composite material
Dibenzo[ b , e ]oxepine derivatives have been constructed efficiently by one‐pot tandem carbon–carbon bond formation reactions. First, 2‐(3,5‐dimethoxybenzyloxy)benzaldehydes were treated with various nucleophiles under I 2 catalysis and then 1‐(3,5‐dimethoxybenzyloxy)‐3,5‐dimethoxybenzene was treated with several aromatic as well as heteroaromatic aldehydes under BF 3 · Et 2 O catalytic conditions to provide dibenzo[ b , e ]oxepines in good yields.