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Biologically Active Macrocyclic Compounds – from Natural Products to Diversity‐Oriented Synthesis
Author(s) -
Madsen Charlotte M.,
Clausen Mads H.
Publication year - 2011
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201001715
Subject(s) - chemistry , biological activity , combinatorial chemistry , organic chemistry , nanotechnology , biochemistry , in vitro , materials science
Macrocyclic compounds are attractive targets when searching for molecules with biological activity. The interest in this compound class is increasing, which has led to a variety of methods for tackling the difficult macrocyclization step in their synthesis. This microreview highlights some recent developments in the synthesis of macrocycles, with an emphasis on chemistry developed to generate libraries of putative biologically active compounds.