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Dynamic Kinetic Resolution of β‐Amino Esters by a Heterogeneous System of a Palladium Nanocatalyst and Candida antarctica Lipase A
Author(s) -
Engström Karin,
Shakeri Mozaffar,
Bäckvall JanE.
Publication year - 2011
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201001714
Subject(s) - candida antarctica , kinetic resolution , chemistry , racemization , lipase , catalysis , palladium , yield (engineering) , organic chemistry , enzyme catalysis , biocatalysis , amino esters , combinatorial chemistry , enzyme , enantioselective synthesis , reaction mechanism , thermodynamics , physics
A dynamic kinetic resolution (DKR) of β‐amino esters have been developed by the use of a heterogeneous racemization catalyst and an immobilized enzyme that accepts aromatic, heteroaromatic and aliphatic substrates. The reaction conditions were optimized to yield an efficient catalytic system without by‐product formation. The products are obtained in 96–99 % ee and high yields.