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Highly Efficient Total Synthesis of the Clostridium ‐Derived anti‐MRSA Antibiotic Closthioamide
Author(s) -
Kloss Florian,
Lincke Thorger,
Hertweck Christian
Publication year - 2011
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201001695
Subject(s) - chemistry , clostridium , antibiotics , anaerobic bacteria , metabolite , microbiology and biotechnology , bacteria , combinatorial chemistry , biochemistry , biology , genetics
The antibiotic closthioamide from Clostridium cellulolyticum , the first example of a secondary metabolite from strictly anaerobic bacteria, was synthesized by a versatile and highly efficient synthetic route. This starts from simple building blocks and involves convergent peptide coupling and polythionation.