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An Efficient Copper‐Catalyzed Cross‐Coupling Reaction of Thiols with Aryl Iodides
Author(s) -
Kao HsinLun,
Chen ChinKeng,
Wang YuJen,
Lee ChinFa
Publication year - 2011
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201001667
Subject(s) - chemistry , aryl , catalysis , steric effects , copper , coupling reaction , combinatorial chemistry , organic chemistry , reaction conditions , polymer chemistry , alkyl
Commercially available Cu 2 O powder is a very reactive catalyst for the coupling of thiols to aryl iodides. A variety of functional groups including esters, unprotected amines, alcohols, and heterocycles tolerate the reaction conditions. Moreover, di‐ ortho ‐substituted aryl iodides with sterically demanding substrates were also coupled to give the desired aryl thioethers in good to excellent yields.