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Modular Synthesis of Bifunctional Linkers for Materials Science
Author(s) -
Moreau Julie,
MarchandBrynaert Jacqueline
Publication year - 2011
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201001666
Subject(s) - chemistry , bifunctional , maleimide , thioctic acid , combinatorial chemistry , phosphonate , nitrilotriacetic acid , amide , ethylene glycol , alkyl , organic chemistry , lipoic acid , chelation , antioxidant , catalysis
A practical synthesis of α,ω‐bifunctional linkers is described that is based on three building blocks, namely, thioctic acid, a spacer‐arm of seven ethylene glycol units, and a functional motif dedicated to the selective immobilization of purposely tagged proteins. Such representative motifs are biotin, haloacetamide, maleimide, and nitrilotriacetic acid derivatives. The building blocks are connected through alkyl, amide, and/or carbamate linkages.