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Selective Chemical Oxidation of Risperidone: A Straightforward and Cost‐Effective Synthesis of Paliperidone
Author(s) -
Riva Renata,
Banfi Luca,
Castaldi Graziano,
Ghislieri Diego,
Malpezzi Luciana,
Musumeci Francesca,
Tufaro Roberto,
Rasparini Marcello
Publication year - 2011
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201001618
Subject(s) - paliperidone , risperidone , chemistry , paliperidone palmitate , combinatorial chemistry , schizophrenia (object oriented programming) , psychiatry , psychology
Abstract A very short and cost‐effective synthesis of the commercial drug paliperidone has been achieved starting from its parent compound risperidone, through a thoroughly optimized oxidation with air under basic conditions.