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A Clean, Highly Efficient and One‐Pot Green Synthesis of Aryl/Alkyl/Heteroaryl‐Substituted Bis(6‐amino‐1,3‐dimethyluracil‐5‐yl)methanes in Water
Author(s) -
Das Subrata,
Thakur Ashim Jyoti
Publication year - 2011
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201001581
Subject(s) - chemistry , alkyl , aryl , condensation , catalysis , organic chemistry , green chemistry , medicinal chemistry , reaction mechanism , physics , thermodynamics
A highly efficient green synthesis of aryl/alkyl/heteroaryl‐substituted bis(6‐amino‐1,3‐dimethyluracil‐5‐yl)methanes by the condensation of 6‐amino‐1,3‐dimethyluracil with aldehydes (aromatic, aliphatic and heterocyclic) in water at room temperature is described. No dehydrating agent, heat, catalyst, surfactant or additive was used. The structures of the compounds were established by spectroscopic methods and single‐crystal X‐ray crystallography.