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Nucleophilic Trifluoromethylation of C=N Bonds
Author(s) -
Dilman Alexander D.,
Levin Vitalij V.
Publication year - 2011
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201001558
Subject(s) - trifluoromethylation , chemistry , iminium , carbanion , nucleophile , reagent , nucleophilic addition , combinatorial chemistry , medicinal chemistry , organic chemistry , ion , trifluoromethyl , catalysis , alkyl
The review covers nucleophilic addition reactions of the CF 3 carbanion to C=N bonds. Trifluoromethylation reactions of imines, nitrones, hydrazones, iminium ions and azomethine ylides are discussed. Various trifluorometylating reagents are considered, among which the major emphasis is placed on reactions using the Ruppert–Prakash reagent.