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Room‐Temperature Nickel‐Catalysed Suzuki–Miyaura Reactions of Aryl Sulfonates/Halides with Arylboronic Acids
Author(s) -
Fan XinHeng,
Yang LianMing
Publication year - 2011
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201001519
Subject(s) - chemistry , aryl , halide , reagent , toluene , catalysis , nickel , base (topology) , organic chemistry , coupling reaction , combinatorial chemistry , medicinal chemistry , polymer chemistry , alkyl , mathematics , mathematical analysis
Room‐temperature Suzuki–Miyaura aryl–aryl cross‐coupling reactions have been achieved in high yields by using an easily accessible, air‐stable Ni II –(σ‐aryl) complex as precatalyst without either the pretreatment of organometallic reagents or the presence of external reductants. The Ni II complex, in conjunction with monophosphane ligands such as PCy 3 · HBF 4 or PPh 3 , allowed the efficient cross‐coupling of aryl sulfonates (OTs, OMs) and/or halides (Cl, Br, I) with arylboronic acids at room temperature in toluene/water in the presence of K 2 CO 3 as base.