Synthesis of 2‐Amino‐3‐cyano‐4 H ‐chromene‐4‐carboxamide Derivatives by an Isocyanide‐Based Domino Conjugate Addition/O‐Trapping Rearrangement Sequence | Zendy

Gyuris Márió | Zendy; Madácsi Ramóna | Zendy; Puskás László G. | Zendy; Tóth Gábor K. | Zendy; Wölfling János | Zendy; Kanizsai Iván | Zendy

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Synthesis of 2‐Amino‐3‐cyano‐4 H ‐chromene‐4‐carboxamide Derivatives by an Isocyanide‐Based Domino Conjugate Addition/O‐Trapping Rearrangement Sequence

Author(s) -

Gyuris Márió,

Madácsi Ramóna,

Puskás László G.,

Tóth Gábor K.,

Wölfling János,

Kanizsai Iván

Publication year - 2011

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201001502

Subject(s) - chemistry , conjugate , isocyanide , intramolecular force , domino , carboxamide , trapping , stereochemistry , combinatorial chemistry , medicinal chemistry , organic chemistry , catalysis , mathematical analysis , ecology , mathematics , biology

An efficient, one‐pot domino synthesis of new 2‐amino‐3‐cyano‐4 H ‐chromene‐4‐carboxamide derivatives has been developed by the acid‐induced conjugate addition of isocyanides to 2‐imino‐2 H ‐chromene‐3‐carboxamides, followed by an intramolecular O‐trapping rearrangement, with yields up to 92 %. This newly established protocol was also used in multicomponent (3CR) mode.

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