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Synthesis of Sulfones by Iron‐Catalyzed Decomposition of Sulfonylhydrazones
Author(s) -
Barluenga José,
TomásGamasa María,
Aznar Fernando,
Valdés Carlos
Publication year - 2011
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201001492
Subject(s) - chemistry , carbene , catalysis , nucleophile , decomposition , aryl , alkyl , nucleophilic addition , sulfone , medicinal chemistry , intermolecular force , organic chemistry , combinatorial chemistry , molecule
The Fe‐catalyzed decomposition of sulfonylhydrazones gives rise to sulfones. The reaction is quite general and allows the preparation of sulfones from a variety of aryl, alkyl, and α,β‐unsaturated aldehydes and ketones. Crossover experiments reveal that the reaction is an intermolecular process, which may proceed by nucleophilic attack of the sulfinate anion on an iron carbene complex.