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N‐Heterocyclic Carbene Catalyzed Domino Reactions of Formylcyclopropane 1,1‐Diesters: Construction of a 6‐5‐5 Tricyclic Pyrrolo[1,2‐ a ]indole
Author(s) -
Li Linxia,
Du Ding,
Ren Jun,
Wang Zhongwen
Publication year - 2011
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201001364
Subject(s) - chemistry , knoevenagel condensation , indole test , domino , carbene , tricyclic , catalysis , ring (chemistry) , redox , organic chemistry , combinatorial chemistry , medicinal chemistry
Catalyzed by N‐heterocyclic carbenes (NHCs), a domino ring‐opening/redox amidation/Knoevenagel condensation of readily available formylcyclopropane 1,1‐diesters with 1 H ‐indole‐2‐carbaldehydes is reported. This methodology provides a new and direct method for the construction of a 6‐5‐5 tricyclic pyrrolo[1,2‐ a ]indole skeleton.