N‐Heterocyclic Carbene Catalyzed Domino Reactions of Formylcyclopropane 1,1‐Diesters: Construction of a 6‐5‐5 Tricyclic Pyrrolo[1,2‐ a ]indole | Zendy

Li Linxia | Zendy; Du Ding | Zendy; Ren Jun | Zendy; Wang Zhongwen | Zendy

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N‐Heterocyclic Carbene Catalyzed Domino Reactions of Formylcyclopropane 1,1‐Diesters: Construction of a 6‐5‐5 Tricyclic Pyrrolo[1,2‐ a ]indole

Author(s) -

Li Linxia,

Du Ding,

Ren Jun,

Wang Zhongwen

Publication year - 2011

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201001364

Subject(s) - chemistry , knoevenagel condensation , indole test , domino , carbene , tricyclic , catalysis , ring (chemistry) , redox , organic chemistry , combinatorial chemistry , medicinal chemistry

Catalyzed by N‐heterocyclic carbenes (NHCs), a domino ring‐opening/redox amidation/Knoevenagel condensation of readily available formylcyclopropane 1,1‐diesters with 1 H ‐indole‐2‐carbaldehydes is reported. This methodology provides a new and direct method for the construction of a 6‐5‐5 tricyclic pyrrolo[1,2‐ a ]indole skeleton.

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