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Viburspiran, an Antifungal Member of the Octadride Class of Maleic Anhydride Natural Products
Author(s) -
Saleem Muhammad,
Hussain Hidayat,
Ahmed Ishtiaq,
Draeger Siegfried,
Schulz Barbara,
Meier Kathrin,
Steinert Michael,
Pescitelli Gennaro,
Kurtán Tibor,
Flörke Ulrich,
Krohn Karsten
Publication year - 2011
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201001324
Subject(s) - botrytis cinerea , maleic anhydride , chemistry , antifungal , organic chemistry , stereochemistry , botany , microbiology and biotechnology , biology , copolymer , polymer
Viburspiran ( 8 ), a structurally new member of the maleic anhydride natural products, was isolated, along with seven known compounds 9 – 15 , from the fungal endophyte Cryptosporiopsis sp. The structure of the new compound was elucidated by spectroscopic methods and confirmed by single‐crystal X‐ray analysis. The absolute configuration was established by TDDFT CD calculations by using the solid‐state structure for input geometry. Viburspiran ( 8 ) is the first representative of a new class of eight‐membered maleic anhydride natural products, named octadrides and exhibited antifungal activity against Botrytis cinerea and Microbotryum violaceum .