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Sodium Hydride Catalyzed Tishchenko Reaction
Author(s) -
Werner Thomas,
Koch Juliane
Publication year - 2010
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201001294
Subject(s) - chemistry , hydride , sodium hydride , catalysis , sodium , reaction conditions , organic chemistry , combinatorial chemistry , metal
A convenient and practical method for the dimerization of aldehydes is described. The conversion of aromatic and even heteroaromatic aldehydes in the presence of catalytic amounts of sodium hydride leads to the corresponding Tishchenko esters in high yields (up to 95 %). The reaction can be performed under standard laboratory conditions and on a multigram scale (up to 10 g).