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Efficient Copper‐Catalyzed Direct Amination of Aryl Halides Using Aqueous Ammonia in Water
Author(s) -
Meng Fei,
Zhu Xinhai,
Li Ying,
Xie Jianwei,
Wang Bo,
Yao Junhua,
Wan Yiqian
Publication year - 2010
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201001150
Subject(s) - chemistry , amination , aryl , halide , ammonia , catalysis , aqueous solution , copper , organic chemistry , aqueous medium , combinatorial chemistry , alkyl
Abstract The N 2 ,N 2 ′ ‐diisopropyloxalohydrazide/CuO system efficiently catalyzed the direct amination of aryl bromides andiodides with aqueous ammonia in water at 60 °C in 24 h or at 120 °C in only 20–30 min. Both activated and unactivated aryl and heteroaryl bromides and iodides were readily aminated in good to excellent yields.