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Uncatalyzed One‐Pot Diastereoselective Synthesis of α‐Amino Phosphonates Under Solvent‐Free Conditions
Author(s) -
Tibhe Gaurao D.,
LagunasRivera Selene,
VargasDíaz Elena,
GarcíaBarradas Oscar,
Ordoñez Mario
Publication year - 2010
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201001096
Subject(s) - chemistry , methylamines , solvent , organic chemistry , catalysis , reaction conditions
Uncatalyzed one‐pot, three‐component reactions of aldehydes, chiral α‐methylamines, and dimethyl phosphite under solvent‐free conditions were used for the diastereoselective synthesis of α‐amino phosphonates. The reactions proceeded with extremely high efficiency under mild conditions and gave good yields and diastereoselectivities (70:30 to 93:7 dr ). This approach could be useful for the large‐scale synthesis of several α‐amino phosphonates.