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Copper(II) Triflate Catalyzed Intermolecular Aromatic Substitution of N , N ‐Disubstituted Anilines with Diazo Esters
Author(s) -
Tayama Eiji,
Yanaki Tomoyo,
Iwamoto Hajime,
Hasegawa Eietsu
Publication year - 2010
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201001083
Subject(s) - chemistry , diazo , trifluoromethanesulfonate , intermolecular force , catalysis , medicinal chemistry , copper , yield (engineering) , organic chemistry , molecule , materials science , metallurgy
The intermolecular aromatic substitution of N , N ‐disubstituted anilines with diazo esters is achieved under mild conditions in the presence of a catalytic amount of copper(II) triflate (up to 89 % yield). The scope and limitations regarding substrates, diazo esters, and ligands in this reaction are described.