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Microwave‐Assisted Diversity‐Oriented Domino Synthesis of Functionalized Nicotinic Acid Derivatives
Author(s) -
Tejedor David,
MéndezAbt Gabriela,
GarcíaTellado Fernando
Publication year - 2010
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201001067
Subject(s) - domino , chemistry , propargyl , alkyl , ring (chemistry) , cascade reaction , combinatorial chemistry , organic chemistry , catalysis
The microwave‐assisted diversity‐oriented domino synthesis of functionalized alkyl nicotinates from propargyl vinyl ethers is described. The domino manifold comprises a complex network of reactions involving at least five distinct chemical steps. The obtained alkyl nicotinates incorporate two diversity points at the ring and one ester functionality as convenient handles for further elaboration.