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Facile Synthesis of 1‐(Isoquinolin‐1‐yl)ureas by Silver Triflate Catalyzed Tandem Reactions of 2‐Alkynylbenzaldoximes with Carbodiimides
Author(s) -
Ye Shengqing,
Wang Huanhuan,
Wu Jie
Publication year - 2010
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201001040
Subject(s) - chemistry , trifluoromethanesulfonate , tandem , cycloaddition , catalysis , combinatorial chemistry , cascade reaction , organic chemistry , materials science , composite material
2‐Alkynylbenzaldoximes react with carbodiimides under mild conditions and silver triflate catalysis in DMF, leading to a diverse range of 1‐(isoquinolin‐1‐yl)ureas in good to excellent yields. This transformation involves tandem 6‐ endo cyclization, [3+2] cycloaddition, and subsequent rearrangement.