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Pd/Cu‐Catalyzed Direct Alkenylation of Azole Heterocycles with Alkenyl Halides
Author(s) -
Sahnoun Sophian,
Messaoudi Samir,
Brion JeanDaniel,
Alami Mouâd
Publication year - 2010
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201000959
Subject(s) - chemistry , azole , halide , catalysis , medicinal chemistry , chloride , organic chemistry , combinatorial chemistry , antifungal , medicine , dermatology
Direct alkenylation of azole heterocycles through Pd–Cu‐catalyzed C–H bond activation has been reported using alkenyl bromides as the coupling partners. The reaction enables the introduction of various mono‐, di‐, or trisubstituted alkenyl bromides as well as a benzyl chloride to the caffeine core.