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A Tandem Michael–S N 2‐Mediated General Route to Six‐Membered Heterocycles and Carbocycles
Author(s) -
Atta Ananta Kumar,
Pathak Tanmaya
Publication year - 2010
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201000941
Subject(s) - chemistry , tandem , michael reaction , stereoselectivity , combinatorial chemistry , sequence (biology) , organic chemistry , stereochemistry , catalysis , biochemistry , materials science , composite material
A powerful, flexible, and stereoselective general strategy for the construction of chirally pure six‐membered heterocycles and carbocycles by utilizing a tandem Michael–S N 2 sequence is described. The strategy avoids the tedious synthesis of separate starting materials prior to cyclization. The expedient and general strategy, which is virtually untapped until now, will enrich the arsenal of synthetic chemists for the preparation of cyclic compounds.