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Convergent Total Synthesis of Murisolin
Author(s) -
Quinn Kevin J.,
Islamaj Livio,
Couvertier Shalise M.,
Shanley Kathleen E.,
Mackinson Brendan L.
Publication year - 2010
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201000875
Subject(s) - acetogenin , chemistry , tetrahydrofuran , convergent synthesis , total synthesis , metathesis , stereochemistry , sequence (biology) , organic chemistry , polymerization , annonaceae , medicine , biochemistry , polymer , solvent , traditional medicine
A convergent total synthesis of the mono(tetrahydrofuran) annonaceous acetogenin murisolin, with a longest linear sequence of nine steps, is reported. Assembly of the complete carbon framework by cross metathesis and late‐stage tetrahydrofuran formation on the intact backbone are key elements of the synthesis.