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Solvent‐Free Chemoselective Cyanation of α,α‐Dibromoacetophenones Using Potassium Hexacyanoferrate(II) as an Eco‐Friendly Cyanide Source
Author(s) -
Zhao Zhouxing,
Li Zheng
Publication year - 2010
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201000848
Subject(s) - cyanation , chemistry , cyanide , environmentally friendly , solvent , catalysis , aryl , potassium cyanide , organic chemistry , potassium , combinatorial chemistry , ecology , alkyl , biology
A chemoselective route for the synthesis of 2‐aryl‐3,3‐dibromoacrylonitriles by solvent‐free cyanation of α,α‐dibromoacetophenones by using potassium hexacyanoferrate(II) as an eco‐friendly cyanide source is developed. The merits of this procedure include avoiding the use of a strong toxic cyanide source, a catalyst, and volatile organic solvents and the high yields of the products.