Oxepinamides: Novel Liver X Receptor Agonists from  Aspergillus puniceus | Zendy

Lu XinHua | Zendy; Shi QingWen | Zendy; Zheng ZhiHui | Zendy; Ke AiBing | Zendy; Zhang Hua | Zendy; Huo ChangHong | Zendy; Ma Ying | Zendy; Ren Xiao | Zendy; Li YeYing | Zendy; Lin Jie | Zendy; Jiang Qin | Zendy; Gu YuCheng | Zendy; Kiyota Hiromasa | Zendy

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Oxepinamides: Novel Liver X Receptor Agonists from Aspergillus puniceus

Author(s) -

Lu XinHua,

Shi QingWen,

Zheng ZhiHui,

Ke AiBing,

Zhang Hua,

Huo ChangHong,

Ma Ying,

Ren Xiao,

Li YeYing,

Lin Jie,

Jiang Qin,

Gu YuCheng,

Kiyota Hiromasa

Publication year - 2011

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201000812

Subject(s) - chemistry , liver x receptor , stereochemistry , aspergillus , receptor , nuclear receptor , biochemistry , transcription factor , gene , microbiology and biotechnology , biology

Four novel oxepin‐containing pyrimidines, namely oxepinamides D–G ( 1 – 4 ), were isolated from cultures of Aspergillus puniceus F02Z‐1744. The structures of 1 – 4 were elucidated by analyzing their spectroscopic data generated by 1D and 2D NMR and MS methods. The configurations of 1 and 2 were established based on single‐crystal X‐ray crystallographic analysis. All four compounds 1 – 4 showed transcriptional activation on Liver X Receptor α (LXRα) with EC 50 values of 10.6, 12.8, 13.6, and 12.1 μ M , respectively.

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