Synthesis of 2‐, 3‐, and 4‐Substituted Pyrido[2,3‐ b ]indoles by C–N, C–O, and C–C(sp) Bond Formation | Zendy

Schneider Cédric | Zendy; Goyard David | Zendy; Gueyrard David | Zendy; Joseph Benoît | Zendy; Goekjian Peter G. | Zendy

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Synthesis of 2‐, 3‐, and 4‐Substituted Pyrido[2,3‐ b ]indoles by C–N, C–O, and C–C(sp) Bond Formation

Author(s) -

Schneider Cédric,

Goyard David,

Gueyrard David,

Joseph Benoît,

Goekjian Peter G.

Publication year - 2010

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201000795

Subject(s) - sonogashira coupling , chemistry , regioselectivity , stereochemistry , indole test , medicinal chemistry , palladium , organic chemistry , catalysis

The synthesis of 2‐, 3‐, and 4‐substituted α‐carbolines is described starting from the corresponding chloropyrido[2,3‐ b ]indoles by Buchwald–Hartwig and Sonogashira cross‐coupling reactions. Regioselective Sonogashira reactions on 2,4‐dichloropyrido[2,3‐ b ]indoles are also presented as an efficient route to unsymmetrically 2,4‐disubstituted α‐carbolines.

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