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Efficient Copper‐Catalyzed Cross‐Coupling Reaction of Alkynes with Aryl Iodides
Author(s) -
Lin CheHung,
Wang YuJen,
Lee ChinFa
Publication year - 2010
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201000653
Subject(s) - xantphos , chemistry , aryl , catalysis , copper , steric effects , coupling reaction , combinatorial chemistry , coupling (piping) , polymer chemistry , medicinal chemistry , organic chemistry , palladium , mechanical engineering , alkyl , engineering
A copper‐catalyzed cross‐coupling reaction of alkynes with aryl iodides is described. The system tolerates a broad range of functional groups and enables the use of sterically demanding substrates with only 1.0–2.5 mol‐% of Cu 2 O and 1.0–2.5 mol‐% of xantphos as the catalyst.