Premium
Efficient Copper‐Catalyzed Cross‐Coupling Reaction of Alkynes with Aryl Iodides
Author(s) -
Lin CheHung,
Wang YuJen,
Lee ChinFa
Publication year - 2010
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201000653
Subject(s) - xantphos , chemistry , aryl , catalysis , copper , steric effects , coupling reaction , combinatorial chemistry , coupling (piping) , polymer chemistry , medicinal chemistry , organic chemistry , palladium , mechanical engineering , alkyl , engineering
A copper‐catalyzed cross‐coupling reaction of alkynes with aryl iodides is described. The system tolerates a broad range of functional groups and enables the use of sterically demanding substrates with only 1.0–2.5 mol‐% of Cu 2 O and 1.0–2.5 mol‐% of xantphos as the catalyst.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom