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Metal‐Free Synthesis of Imido Derivatives by Direct Oxidation of α‐Amido Sulfones
Author(s) -
Martinelli Fabio,
Palmieri Alessandro,
Petrini Marino
Publication year - 2010
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201000634
Subject(s) - chemistry , metal , oxidation process , combinatorial chemistry , ion , organic chemistry , medicinal chemistry , chemical engineering , engineering
Oxidation of α‐amidoaryl sulfones with m ‐chloroperoxybenzoic acid under mild conditions readily provides the corresponding imides in satisfactory yields. The overall process probably involves formation of an N ‐acyliminium ion intermediate, which by attack of the peroxyacid anion generates the final imido derivatives.