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Palladium‐Catalyzed Regioselective C–H Bond ortho ‐Acetoxylation of Arylpyrimidines
Author(s) -
Zheng Xiaojian,
Song Bingrui,
Xu Bin
Publication year - 2010
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201000631
Subject(s) - regioselectivity , chemistry , palladium , catalysis , functional group , medicinal chemistry , organic chemistry , combinatorial chemistry , polymer
An efficient and regioselective palladium‐catalyzed ortho C–H acetoxylation reaction was developed to afford ortho monoacetoxylated arylpyrimidines in good to excellent yields by using cupric trifluoroacetate as a cocatalyst. A wide variety of oxygenated arylpyrimidines were prepared with high regioselectivity and functional group tolerance.