Palladium‐Catalyzed Bis‐Functionalization of Isatylidenes: A Facile Route towards Spiro‐Indol‐2‐ones | Zendy

George Sholly Clair | Zendy; John Jubi | Zendy; Anas Saithalavi | Zendy; John Joshni | Zendy; Yamamoto Yoshinori | Zendy; Suresh Eringathodi | Zendy; Radhakrishnan K. V. | Zendy

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Palladium‐Catalyzed Bis‐Functionalization of Isatylidenes: A Facile Route towards Spiro‐Indol‐2‐ones

Author(s) -

George Sholly Clair,

John Jubi,

Anas Saithalavi,

John Joshni,

Yamamoto Yoshinori,

Suresh Eringathodi,

Radhakrishnan K. V.

Publication year - 2010

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201000604

Subject(s) - chemistry , palladium , catalysis , metathesis , ring closing metathesis , cyclohexene , surface modification , amphiphile , combinatorial chemistry , salt metathesis reaction , ring (chemistry) , organic chemistry , polymerization , copolymer , polymer

An effective protocol has been developed for the construction of 3,3‐disubstituted indol‐2‐ones from isatylidenes by utilizing amphiphilic bis‐π‐allylpalladium and related intermediates. The developed strategy is a new method for the quaternization of position 3 of the indol‐2‐one towards disubstituted functionalized indol‐2‐ones. These products were subjected to ring‐closing metathesis towards the synthesis of spiro[cyclohexene‐1,3′‐indol]‐2′‐ones and spiro[oxep‐5‐ene‐2,3′‐indol]‐2′‐ones, which are of biological interest.

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