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A Concise Asymmetric Synthesis of (–)‐Hongconin and (–)‐1‐ epi ‐Hongconin
Author(s) -
Fernandes Rodney A.,
Chavan Vijay P.
Publication year - 2010
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201000560
Subject(s) - chemistry , enantioselective synthesis , stereochemistry , total synthesis , combinatorial chemistry , organic chemistry , catalysis
A concise asymmetric synthesis of (–)‐hongconin and (–)‐1‐ epi ‐hongconin is described. The synthesis features an efficient combination of Dötz benzannulation or lactaldehyde arylation and the oxa‐Pictet–Spengler reaction as the key steps. The synthesis is completed in 10–11 steps from the chiral pool material ( R )‐methyl lactate.